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Zinc triflate catalyzed aerobic cross-dehydrogenative coupling (CDC) of alkynes with nitrones: A new entry to isoxazoles
, A. Studer
Published in
Volume: 13
Issue: 10
Pages: 2746 - 2749
A mild, operationally simple cross-dehydrogenative coupling between nitrones and terminal alkynes is described by using cheap, readily available 3,3′,5,5′-tetra-tert-butyldipheno-quinone and dioxygen as oxidants. These cross-couplings can be performed on various nitrones and alkynes with good to excellent yields. Product nitrones are readily transformed to pharmaceutically important 3,5-disubstituted isoxazoles. © 2011 American Chemical Society.
About the journal
JournalOrganic Letters