The DNA molecule, apart from carrying the genetic information, plays a crucial role in a variety of biological processes and finds applications in drug design, nanotechnology and nanoelectronics. The molecule undergoes significant structural transitions under the influence of forces due to physiological and non-physiological environments. Here, we summarize the insights gained from simulations and single-molecule experiments on the structural transitions and mechanics of DNA under force, as well as its elastic properties, in various environmental conditions, and discuss appealing future directions. © 2020 Elsevier Ltd

Santosh Mogurampelly

Department of Physics

IIT Jodhpur

A. Aggarwal

S. Naskar

A.K. Sahoo

A. Garai

P.K. Maiti

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Current Opinion in Structural Biology

What do we know about DNA mechanics so far?

Journal	Data powered by TypesetCurrent Opinion in Structural Biology
Publisher	Data powered by TypesetElsevier Ltd
ISSN	0959440X
Open Access	No