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Tripodal molecular propellers perturb microtubule dynamics: Indole acts as a blade and plays a crucial role in anticancer activity
S. Barman, G. Das, P. Mondal, K. Pradhan, B. Jana, D. Bhunia, A. Saha, C. Kar,
Published in Royal Society of Chemistry
PMID: 30724319
Volume: 55
Issue: 16
Pages: 2356 - 2359
An indole-rich tripodal microtubule inhibitor is designed, which binds at the DCVJ site of tubulin and inhibits its polymerization. It causes apoptotic death of cancer cells without affecting normal cells and inhibits the growth of tumors. Finally, STD-NMR and TR-NOESY experiments reveal that the indole appendages play a crucial role in interacting with tubulin. © 2019 The Royal Society of Chemistry.
About the journal
JournalData powered by TypesetChemical Communications
PublisherData powered by TypesetRoyal Society of Chemistry