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Transition metal-free TEMPO-catalyzed oxidative cross-coupling of nitrones with alkynyl-grignard reagents
, A. Studer
Published in
Volume: 353
Issue: 14-15
Pages: 2708 - 2714
An efficient mild one-pot protocol for the cross-coupling of nitrones and alkynyl-magnesium compounds using a catalytic amount of 2,2,6,6- tetramethylpiperidine-N-oxyl radical (TEMPO) as an environmentally benign organic oxidant and dioxygen as terminal oxidant is described. These coupling reactions can be performed without adding any transition metal on various N-tert-butylnitrones and alkynyl-Grignard reagents. Moreover, the alkynylated nitrone products are readily transformed to regioisomerically pure 3,5-disubstituted isoxazoles. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
About the journal
JournalAdvanced Synthesis and Catalysis