An efficient mild one-pot protocol for the cross-coupling of nitrones and alkynyl-magnesium compounds using a catalytic amount of 2,2,6,6- tetramethylpiperidine-N-oxyl radical (TEMPO) as an environmentally benign organic oxidant and dioxygen as terminal oxidant is described. These coupling reactions can be performed without adding any transition metal on various N-tert-butylnitrones and alkynyl-Grignard reagents. Moreover, the alkynylated nitrone products are readily transformed to regioisomerically pure 3,5-disubstituted isoxazoles. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Sandip Murarka

Department of Chemistry

IIT Jodhpur

A. Studer

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Journal	Advanced Synthesis and Catalysis
ISSN	16154150