In recent years, two-dimensional (2D) layered materials, such as MoS2, MoSe2, WS2, WSe2, SnS2, etc., have gained enormous interest in sensing applications with low-power consumption owing to their unique electrical, chemical, and mechanical properties. Among a broad range of sensors, rapid advances in flexible and wearable sensors have paved the way for smart sensing applications, including electronic skin (e-skin), home security, air- and health-monitoring, etc. This review aims at summarizing recent progress in energy-efficient flexible gas sensors by utilizing 2D transition metal dichalcogenides (TMDCs) materials. Main concepts and different approaches are overviewed for optimizing the gas sensing characteristics on flexible sensing platforms. The different strategies and challenges for incorporating 2D TMDCs materials into e-skin-oriented and e-textiles gas sensors are also highlighted. In addition, this review also includes the challenges and future perspectives for TMDCs materials in emerging flexible and wearable gas sensing field. © 2020 Elsevier B.V.