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Temporal cascade of frontal, motor and muscle processes underlying human action-stopping
S. Jana, R. Hannah, , A.R. Aron
Published in eLife Sciences Publications Ltd
2020
PMID: 32186515
Volume: 9
   
Abstract
Action-stopping is a canonical executive function thought to involve top-down control over the motor system. Here we aimed to validate this stopping system using high temporal resolution methods in humans. We show that, following the requirement to stop, there was an increase of right frontal beta (~13 to 30 Hz) at ~120 ms, likely a proxy of right inferior frontal gyrus; then, at 140 ms, there was a broad skeletomotor suppression, likely reflecting the impact of the subthalamic nucleus on basal ganglia output; then, at ~160 ms, suppression was detected in the muscle, and, finally, the behavioral time of stopping was ~220 ms. This temporal cascade supports a physiological model of action-stopping, and partitions it into subprocesses that are isolable to different nodes and are more precise than the behavioral latency of stopping. Variation in these subprocesses, including at the single-trial level, could better explain individual differences in impulse control. © 2020, eLife Sciences Publications Ltd. All rights reserved.
About the journal
JournaleLife
PublishereLife Sciences Publications Ltd
ISSN2050084X