This communication describes the synthesis, structural investigation and tubulin binding of purine rare imino-tautomer based Ag(i) and Hg(ii)-carbene complexes. These complexes exhibit cytotoxicity through tubulin interaction by binding to a site close to the GTP binding site. © 2014 The Royal Society of Chemistry.

Surajit Ghosh

Department of Bioscience & Bioengineering

IIT Jodhpur

S. Khanna

B. Jana

A. Saha

P. Kurkute

S. Verma

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Dalton Transactions

Targeting cytotoxicity and tubulin polymerization by metal-carbene complexes on a purine tautomer platform

Journal	Data powered by TypesetDalton Transactions
Publisher	Data powered by TypesetRoyal Society of Chemistry
ISSN	14779226