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Targeting cytotoxicity and tubulin polymerization by metal-carbene complexes on a purine tautomer platform
S. Khanna, B. Jana, A. Saha, P. Kurkute, , S. Verma
Published in Royal Society of Chemistry
PMID: 24854090
Volume: 43
Issue: 26
Pages: 9838 - 9842
This communication describes the synthesis, structural investigation and tubulin binding of purine rare imino-tautomer based Ag(i) and Hg(ii)-carbene complexes. These complexes exhibit cytotoxicity through tubulin interaction by binding to a site close to the GTP binding site. © 2014 The Royal Society of Chemistry.
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JournalData powered by TypesetDalton Transactions
PublisherData powered by TypesetRoyal Society of Chemistry