We present a novel smart transmission technique with seamless handoff mechanism to achieve ubiquitous connectivity using multiple on-chip radios targeting remote health monitoring applications. For the first time to the best of our knowledge, a system architecture for low-power ubiquitously connected multiparametric remote health monitoring system is proposed in this paper. The architecture proposed uses a generic adaptive rule engine for classifying the collected multiparametric data from patient and smartly transmit the data when only needed. The on-chip seamless handoff mechanism proposed aids for the ubiquitous connectivity with a very good energy savings by intelligent controlling of the multiple on-chip radios. The performance analysis of the proposed on-chip seamless handoff mechanism along with adaptive rule engine-based smart transmission mechanism achieves on an average of 50.39% of energy saving and 51.01% reduction in duty cycle of transmitter taken over 20 users compared with the continuous transmission. From the hardware complexity analysis made on the proposed seamless handoff controller and adaptive rule engine concludes that they require only 2082 CMOS transistors for real-time implementation. © 2001-2012 IEEE.