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Synthesis of aminosterols and their derivatives
Shafiullah, , Malik Jamaluddin, H. Ogura, H. Takayanagi
Published in
1990
Volume: 55
   
Issue: 3
Pages: 120 - 122
Abstract
Reactions of steroidal epoxides such as 5,6$\alpha$-epoxy-5$\alpha$-cholestane (I) and its 3$\beta$-chloro (H) and 3$\beta$-acetoxy (III) analogs with urea in dimethylformamide afforded 6$\beta$-amino-5$\alpha$-cholestan-5-ol (IV-VI), 6$\beta$-amino-N-formyl-5$\alpha$-cholestan-5-ol (VII-IX) and 6$\beta$-amino-N-amido-5$\alpha$-cholestan-5-ol (X-XII), along with the 5$\alpha$-cholestane-5,6$\beta$-diol (XIII-XV). In addition to these compounds, the 3$\beta$-acetoxy analog also afforded the N-carboxyl derivative (XVI). {\textcopyright} 1990.
About the journal
JournalSteroids
ISSN0039128X