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Self-assembling soft structures for intracellular NO release and promotion of neurite outgrowth
H.A. Pal, S. Mohapatra, V. Gupta, , S. Verma
Published in Royal Society of Chemistry
Volume: 8
Issue: 9
Pages: 6171 - 6175
Nitric oxide (NO), an endogenously produced free radical species, is an extremely important signalling molecule in several biochemical processes related to neurotransmission, neuronal communication, and vasodilation, to name a few. Other than relying on endogenous synthesis, intracellular NO delivery presents an interesting challenge to fully exploit the therapeutic potential of this gaseous molecule. We have applied a self-assembling peptide conjugate strategy to devise a construct carrying a NO-release arm, which can be activated under standard redox conditions. Consequently, a tryptophan-based peptide carrier was designed, which self-assembled in the solution phase to afford soft nanospherical structures, and released NO in Neuro2a cell line, resulting in neurite outgrowth. © 2017 The Royal Society of Chemistry.
About the journal
JournalData powered by TypesetChemical Science
PublisherData powered by TypesetRoyal Society of Chemistry