In this paper, we investigate the correlation between optimal set of driver nodes and networked sensitivity of Complex Networked Systems (CNS). Here, we study the networked sensitivity between a pair of control and output nodes for interconnected directed and undirected networks. We investigate the importance of the optimal driver nodes based on new index of the networked control system, which is networked sensitivity in the networked system. In this paper, we discuss to select the optimal set of driver nodes corresponding to minimum networked sensitivity w.r.t. (i) maximum DC-Gain and (ii) a range of frequency. In particular, we develop an algorithm to select the optimal set of driver nodes which has minimum networked sensitivity. Finally, we validate theoretical results with the help of network examples. © 2017 IEEE.