Many major river bridges were constructed in highly active seismic areas of India much before the seismic code development. Bridges are lifelines infrastructure and as a result, it is necessary to requalify/reasses these structures in the light of the new and improved understanding of seismic resistant design philosophies. The aim of the paper is to develop a simplified methodology to carry out scenario based seismic requalification of major river bridges supported on caisson foundations (also known as Well Foundation). An example problem of Saraighat Bridge located in highly active Himalayan seismic zone is considered to demonstrate the application of the methodology. Field investigation and advanced laboratory tests on soil samples from the bridge site were carried out. The test results reveal that the soil is susceptible to liquefaction and as a result, soil structure interaction analyses are carried out. It is shown that good performance of these type of bridges depend on the displacement response of the pier head so as not to cause unseating of the decks. It is concluded, owing to the large stiffness of the foundations, bridges supported on caisson foundations may not be adversely affected by liquefaction induced effects. © 2017 Elsevier Ltd