Malignant gliomas are the leading cause of central nervous system (CNS) tumor-related death. The failure of conventional cancer therapeutics results from the aberrant angiogenesis in gliomas. Abnormal vessel structure of gliomas, resulting in decreased delivery of chemotherapies, increased tumor hypoxia and edema leading to further complications. In this study, role of the nucleotide-binding domain, leucine rich containing (NLR) proteins in glioblastoma angiogenesis is studied. Some NLR proteins form a multi-protein complex with procaspase-1, called the “inflammasome”. Aberrant angiogenesis with torturous and leaky vessels and hypoxic core are the hallmarks of glioblastoma. Glioblastoma consists of heterogeneous population of cells such as microglial, endothelial cells, astrocytes, neurons and stromal cells. These characteristics of glioblastoma make them resistant to conventional therapy thereby …