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Relay tricyclic Pd(ii)/Ag(i) catalysis: Design of a four-component reaction driven by nitrene-transfer on isocyanide yields inhibitors of EGFR
D.M. Sawant, S. Sharma, R.S. Pathare, G. Joshi, S. Kalra, S. Sukanya, A.K. Maurya, , V.K. Agnihotri, S. KhanShow More
Published in Royal Society of Chemistry
PMID: 30137112
Volume: 54
Issue: 82
Pages: 11530 - 11533
Synthesis of pyrazolo[1,5-c]quinazolines from four easily available precursors is presented through a one-pot tricyclic Pd(ii)/Ag(i) relay catalysis. The bimetallic relay cascade forges five new chemical bonds by concatenating six discrete chemical steps. The relay catalysis enables four-component assembly of pyrazolo[1,5-c]quinazolines that selectively inhibit EGFR, exhibit apoptosis through the ROS-induced mitochondrial-mediated pathway, and arrest the cell cycle at the G1 phase. © 2018 The Royal Society of Chemistry.
About the journal
JournalData powered by TypesetChemical Communications
PublisherData powered by TypesetRoyal Society of Chemistry
Open AccessNo