Synthesis of pyrazolo[1,5-c]quinazolines from four easily available precursors is presented through a one-pot tricyclic Pd(ii)/Ag(i) relay catalysis. The bimetallic relay cascade forges five new chemical bonds by concatenating six discrete chemical steps. The relay catalysis enables four-component assembly of pyrazolo[1,5-c]quinazolines that selectively inhibit EGFR, exhibit apoptosis through the ROS-induced mitochondrial-mediated pathway, and arrest the cell cycle at the G1 phase. © 2018 The Royal Society of Chemistry.

Ramesh K. Metre

Department of Chemistry

IIT Jodhpur

D.M. Sawant

S. Sharma

R.S. Pathare

G. Joshi

S. Kalra

S. Sukanya

A.K. Maurya

V.K. Agnihotri

S. Khan

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Chemical Communications

Relay tricyclic Pd(ii)/Ag(i) catalysis: Design of a four-component reaction driven by nitrene-transfer on isocyanide yields inhibitors of EGFR

Journal	Data powered by TypesetChemical Communications
Publisher	Data powered by TypesetRoyal Society of Chemistry
ISSN	13597345
Open Access	No