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Receptor-ligand based molecular interaction to discover adjuvant for immune cell TLRs to develop next-generation vaccine
N. Gupta, H. Regar, V.K. Verma, D. Prusty, , V.K. Prajapati
Published in Elsevier B.V.
PMID: 32112848
Volume: 152
Pages: 535 - 545
Human immune cell toll-like receptors (TLRs) provide a novel chance for the development of the vaccine adjuvant engaging TLR signaling. A library of peptides was developed and peptides structure was generated through homology modeling and refinement. Further, these peptides were subjected to receptor-ligand interaction study against human immune cell TLRs using Schrödinger-suite software. Here, we identified the most potent ligands for each human immune cell receptor and identified it as a potent adjuvant. This work portrays the ability of binding of different known protein adjuvants with human TLRs 1‐–10. The significance of the study deals with the identification of adjuvant (ligand) for human TLRs individually which assist in the development of the optimal highly immunogenic vaccine. © 2020 Elsevier B.V.
About the journal
JournalData powered by TypesetInternational Journal of Biological Macromolecules
PublisherData powered by TypesetElsevier B.V.
Open AccessNo