This paper reviews the various fabrication methodologies explored for the polydimethylsiloxane (PDMS) based nanocomposites along with their applications in gas sensing and other associated domains. PDMS is well known polymer for its biocompatibility, durability, transparency, and adoptability to any size and shape via replication technique. Envisioning its potential and prospects in flexible device realization, this review discusses various methods used by researchers to develop PDMS-based nanocomposites and approaches to improve their functional properties along with their associated applications. This review article aims to provide insights into the state-of-the-art work carried out in this province which will certainly be helpful for researchers in the field of sensing applications. © 2022, The Polymer Society, Taipei.