A simple EDTA precursor based chemical method has been reported for preparation of Mn0.2NixZn(0.8-x)Fe2O4 nanopowders. The influences of microstructure, composition, and measurement temperature on the DC resistivity of the synthesized nanopowders have been investigated. Room temperature resistivity values (ρRT) of the as-synthesized samples were in the order of ~107 Ωcm, Variation of room temperature magnetic parameters, such as saturation magnetization and coercivity, has also been reported with respect to change in Zn2+ concentration.