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Phenyl hydrazine as initiator for direct arene C-H arylation via base promoted homolytic aromatic substitution
A. Dewanji, , D.P. Curran, A. Studer
Published in
PMID: 24251964
Volume: 15
Issue: 23
Pages: 6102 - 6105
A simple and efficient direct radical arylation of unactivated arenes is described which uses cheap and commercially available phenyl hydrazine as an initiator. The reaction occurs through a base promoted homolytic aromatic substitution (BHAS) mechanism involving aryl radicals and aryl radical anions as intermediates and offers a practical approach for preparation of an array of substituted biaryls. © 2013 American Chemical Society.
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JournalOrganic Letters