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Organocatalytic enantioselective transient enolate protonation in conjugate addition of thioacetic acid to a-substituted n-acryloyloxazolidinones
R.A. Unhale, , V.K. Singh
Published in Elsevier Ltd
Volume: 54
Issue: 15
Pages: 1911 - 1915
Organocatalytic conjugate addition of thioacetic acid to a series of a-substituted N-acryloyloxazolidin-2- ones followed by enantioselective protonation has been studied in the presence of thiourea catalysts derived from cinchona alkaloids. Conjugate addition/protonation adducts have been obtained up to 97% ee and high yields. The methodology could serve as an easy and practical route to the syntheses of useful biologically active molecules. © 2013 Elsevier Ltd. All rights reserved.
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JournalData powered by TypesetTetrahedron Letters
PublisherData powered by TypesetElsevier Ltd