The gelation of the vegetable oils using fat crystals has gained significant attention in recent years. These formulations have been explored for food and pharmaceutical applications. The alteration in the properties of palmitic acid (20–40% w/w) and safflower oil oleogels is extensively studied at microscopic and macroscopic levels. The thermal and mechanical stability of the oleogels is improved when the proportion of the palmitic acid content is increased. However, under stress, the fat crystal network junction zones of the oleogels with higher proportions of palmitic acid undergo disruption. The changes in the properties of the oleogels are due to the alteration in the molecular packing, crystallite size, and lattice strain of the fat crystal network. The alteration in the properties is governed by the changes in the extent of inter- and intramolecular hydrogen bonding within the components of the oleogels. The oleogels can demonstrate the ability to deliver the drug, voriconazole, across the corneal tissue. Further, the prepared oleogels are biocompatible to murine fibroblast cells and do not elicit adverse reactions when instilled within the ocular sac of rabbits. The results suggest that the oleogels can be tried as ocular delivery vehicles. Practical Applications: The delivery of drug into the internal structure of the eye is a great challenge for the ophthalmologists. Usually no more than 1% of the drug can be delivered through conventional techniques. Various researchers have proposed the use of lipid-based ocular drug delivery systems. Some of them include solid liquid nanoparticles, emulsions, and liposomes. However, the preparation of these formulations requires a tedious process. Keeping this in mind, it is proposed to synthesize oleogel as probable ocular drug delivery system. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim