Mechanical ventilation is used for patients with a variety of lung diseases. Traditionally, ventilators have been designed to monotonously deliver equalsized breaths. While it may seem intuitive that lungs may benefit from unvarying and stable ventilation pressure strategy, recently it has been reported that variable lung ventilation is advantageous. In this study, we analyze the mean tidal volume in response to different ‘variable ventilation pressure’ strategies. We found that uniformly distributed variability in pressure gives the best tidal volume as compared to that of normal, scale-free, log-normal, and linear distributions. © Springer India 2015.