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Novel tubulin-targeted cell penetrating antimitotic octapeptide
D. Bhunia, S. Mohapatra, P. Kurkute, , B. Jana, P. Mondal, A. Saha, G. Das, S. Ghosh
Published in Royal Society of Chemistry
PMID: 27713939
Volume: 52
Issue: 85
Pages: 12657 - 12660
An antimitotic cell penetrating octapeptide containing single Arg amino acid is discovered, which strongly binds with the exchangeable GTP/GDP binding site of tubulin, inhibits tubulin polymerization, reduces kinesin driven microtubule motility, activates apoptotic and mitotic check point proteins, induces apoptotic death and significantly inhibits the multicellular tumor spheroid growth of HeLa cells. © 2016 Royal Society of Chemistry.
About the journal
JournalData powered by TypesetChemical Communications
PublisherData powered by TypesetRoyal Society of Chemistry