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Multicomponent Synthesis of Biologically Relevant S-Aryl Dithiocarbamates Using Diaryliodonium Salts
Sushanta Parida K., Sonal Jaiswal, Priyanka Singh,
Published in AMER CHEMICAL SOC
2021
Volume: 23
   
Issue: 16
Pages: 6401 - 6406
Abstract
A transition-metal-free one-pot three-component annulation between diaryliodonium triflates, cyclic and acyclic aliphatic amines, and carbon disulfide providing a convenient and efficient access to biologically relevant S-aryl dithiocarbamates is developed. The reaction does not require metal, base, or any other additive and operates under mild and ambient conditions. This methodology is robust, scalable, and exhibits a broad substrate scope. The in silico analysis revealed that the majority of the compounds have a drug-likeness and good ADMET characteristics.
About the journal
JournalORGANIC LETTERS
PublisherAMER CHEMICAL SOC
ISSN1523-7060
Open AccessNo