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Micropattern-controlled local microtubule nucleation, transport, and mesoscale organization
, C. Hentrich, T. Surrey
Published in
PMID: 23294267
Volume: 8
Issue: 4
Pages: 673 - 678
Microtubule organization in living cells is determined by spatial control of microtubule nucleation, their dynamic properties, and transport by molecular motors. Here, we establish a new micropattern-guided method for controlling local microtubule nucleation by spatially confined immobilization of a microtubule polymerase and show that these nucleated microtubules can be transported and organized in space by motor proteins. This assay provides a new platform for deciphering the principles underlying mesoscale microtubule organization. © 2013 American Chemical Society.
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JournalACS Chemical Biology