Metal assisted chemical etched Si nanostructures have been transferred onflexible sheets (adhesive tape) followed by deposition of Au/Ag nanoparticles to make SERS active platform. It shows significant enhancement of Raman signal of glucose in the vicinity of metal nanoparticles due to its coupling with the surface plasmon of nanostructures. SERS detection of glucose is extremely difficult because of its weak Raman cross section and poor adsorption to metal NPs. Fabricated SERS platform was utilized to detect glucose without any label at low concentration 10 micro molar (μM). The developed cost-effective SERS platform has potential applications as a platform device for non-invasive, label free detection of glucose in human fluid for point of care applications. © 2019 IEEE.