We report in this work that the Aβ peptide directly interacts with tubulin close to the vinblastine and GTP/GDP binding site, inhibits the tubulin polymerization rate, induces tubulin aggregation, causes cell shrinking, enhances Mad2, BubR1, p53, and p21 activation in MCF7 cells and induces the apoptotic death of A549, HeLa and MCF7 cells. © The Royal Society of Chemistry 2015.

Surajit Ghosh

Department of Bioscience & Bioengineering

IIT Jodhpur

A. Saha

S. Mohapatra

P. Kurkute

B. Jana

P. Mondal

D. Bhunia

S. Ghosh

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Chemical Communications

Interaction of Aβ peptide with tubulin causes an inhibition of tubulin polymerization and the apoptotic death of cancer cells

Journal	Data powered by TypesetChemical Communications
Publisher	Data powered by TypesetRoyal Society of Chemistry
ISSN	13597345