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Generation of three spinocerebellar ataxia type-12 patients derived induced pluripotent stem cell lines (IGIBi002-A, IGIBi003-A and IGIBi004-A)
D. Kumar, A. Hussain, A.K. Srivastava, , O. Mukherjee, M. Faruq
Published in Elsevier B.V.
PMID: 30130680
Volume: 31
Pages: 216 - 221
Spinocerebellar ataxia type-12 (SCA12) is a neurological disorder caused due to triplet (CAG) repeat expansion in 5’ UTR of PPP2R2B. It is one of the most prominent SCA-subtype in Indian population and till date no patient specific models have been described. Human-induced-pluripotent-stem cell (HiPSC) based disease modelling has become the next generation tool for studying various human pathologies. In the present study we established three SCA12 patient specific iPSC lines. All the generated lines have shown pluripotency markers, normal karyotype, in-vitro three germ layers differentiation potential, vector clearance, SCA12 mutation, parental genomic identity and contamination free culture. © 2018
About the journal
JournalData powered by TypesetStem Cell Research
PublisherData powered by TypesetElsevier B.V.