This paper presents a 2-D finite element (FE) based micro modelling framework for thermo-mechanical response history analysis of solid brick masonry structures subjected to fire. The 2-D FE framework considers geometric and material nonlinearities, and transient states of strain in conjunction with the temperature-dependent material properties. Material nonlinearity within the 2-D FE model is considered by the temperature-dependent total strain rotating crack model. The FE framework is validated against the thermo-mechanical response of a half-scale masonry wall subjected to one-sided fire exposure, and it is observed that the predictions of the FE framework are reasonably accurate. Utilizing the validated FE framework, thermo-mechanical response history characterization is performed on a full-scale masonry wall subjected to one-sided fire exposure. Critical physical phenomena which include thermal bowing, heat diffusion, unit-mortar thermo-mechanical interaction, cracking and stress profiles within the masonry structures are studied intricately. Furthermore, thermo-mechanics within representative volumes enclosing unit as well as mortar and their correlation with the global thermo-mechanical response is studied. Such 2-D micro-scale thermo-mechanical computations on masonry walls followed by a detailed discussion on their thermo-mechanics are one of the novel features of the present study. It is observed that thermal bowing resulted from a complex interaction between thermal dilation and cracking and crushing in the mortar and unit within the masonry structure. © 2020 Elsevier Ltd