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Enantioselective Tandem Oxidation/Michael–Aldol Approaches to Tetrasubstituted Cyclohexanes
, H. Joshi, R.K. Jha, V.K. Singh
Published in Wiley-VCH Verlag
PMID: 28012254
Volume: 23
Issue: 9
Pages: 2040 - 2043
Enantioselective tandem Michael–aldol and oxidative Michael–aldol approaches have been achieved for the formation of diversely substituted cyclohexanes in total regio-, diastereo- and enantioselective fashion. The presence of nitro, hydroxy and keto groups in the product provides a wide scope for further structural transformations. Furthermore, the utility of the catalytic process is demonstrated in the context of enantioselective formal synthesis of ABT-341, a DPP4 inhibitor. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
About the journal
JournalData powered by TypesetChemistry - A European Journal
PublisherData powered by TypesetWiley-VCH Verlag