Header menu link for other important links
Enantioselective access to tetrahydropyrano[2,3-c]pyrazoles via an organocatalytic domino Michael-hydroalkoxylation reaction
, R.K. Jha, H. Joshi, V.K. Singh
Published in Elsevier Ltd
Volume: 58
Issue: 22
Pages: 2135 - 2139
An asymmetric domino Michael-hydroalkoxylation reaction of trans-α-alkynyl-nitroolefins with N-arylpyrazolinones has been accomplished using a chiral bifunctional squaramide catalyst. Under the organocatalytic method, a broad range of tetrahydropyrano[2,3-c]pyrazoles with an exocyclic alkene at the C-6 position were prepared in high yields and excellent stereoselectivities. The presence of an exocyclic double bond and nitro group in the pyranopyrazoles provide a wide scope for further structural transformations. © 2017 Elsevier Ltd
About the journal
JournalData powered by TypesetTetrahedron Letters
PublisherData powered by TypesetElsevier Ltd