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Enantioselective access to tetrahydropyrano[2,3-c]pyrazoles via an organocatalytic domino Michael-hydroalkoxylation reaction
, R.K. Jha, H. Joshi, V.K. Singh
Published in Elsevier Ltd
2017
Volume: 58
   
Issue: 22
Pages: 2135 - 2139
Abstract
An asymmetric domino Michael-hydroalkoxylation reaction of trans-α-alkynyl-nitroolefins with N-arylpyrazolinones has been accomplished using a chiral bifunctional squaramide catalyst. Under the organocatalytic method, a broad range of tetrahydropyrano[2,3-c]pyrazoles with an exocyclic alkene at the C-6 position were prepared in high yields and excellent stereoselectivities. The presence of an exocyclic double bond and nitro group in the pyranopyrazoles provide a wide scope for further structural transformations. © 2017 Elsevier Ltd
About the journal
JournalData powered by TypesetTetrahedron Letters
PublisherData powered by TypesetElsevier Ltd
ISSN00404039