In this paper, a prey-predator model in polluted environment with disease in prey has been proposed and studied. It is assumed that only prey population is prone to disease whereas, both the populations are affected by the pollutant. Boundedness of the solution of the system is discussed. Existence of all possible equilibrium points has been established. Using Routh Hurwitz criterion, local stability of all the possible equilibrium points has been obtained. Also, interior equilibrium point has been proved to be globally asymptotically stable using Lyapunov function. Then time delay has been introduced in the system making the model more realistic. Existence and direction of Hopf bifurcation in the delay model has been established using normal form theory and center manifold theorem. By taking a set of hypothetical and biologically feasible parameters, model has been studied numerically using MATLAB and the effect of pollutant on the system has been deduced. © 2021 the author(s).