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Design of a novel microtubule targeted peptide vesicle for delivering different anticancer drugs
A. Adak, S. Mohapatra, P. Mondal, B. Jana,
Published in Royal Society of Chemistry
PMID: 27153208
Volume: 52
Issue: 48
Pages: 7549 - 7552
A microtubule targeted peptide-based delivery vehicle has been designed using two oppositely charged peptides, which targets tubulin/microtubules, delivers both hydrophilic and hydrophobic drugs into their target site through lysosome at acidic pH. Drug loaded vesicles show a significant anticancer effect compared to control drugs in a 2D monolayer and a 3D spheroid cell. © The Royal Society of Chemistry 2016.
About the journal
JournalData powered by TypesetChemical Communications
PublisherData powered by TypesetRoyal Society of Chemistry