SiO2-Al2O3-B2O3-Na2O based glass sealant compositions were designed for the development of GMJ using extreme vertices methodology. The effect of the glass sealant individual constituent on wettability, Glass transition temperature (Tg), Crystallization temperature (Tc), thermal conductivity, and density was analyzed with the help of analysis of variance technique (ANOVA). The increase in SiO2 constituent in glass sealant decreased the spreading area (mm2) of glass sealant and increased the value of contact angle (θ) formed by glass sealant over the SS304 metal substrate. The Tg and Tc of glass sealant also increased as SiO2 content increased. The addition of B2O3 and Na2O in glass sealant system reduced the Tg and Tc of glass sealant. The developed regression model was validated and it was observed that the experimental and predicted results nearly matched with an error less than 5% in most of the cases. © 2018 Elsevier Ltd and Techna Group S.r.l.