Power Integrity is maintained in a high speed system by designing an efficient decoupling network. This paper provides a generic formulation for decoupling capacitor selection and placement problem which is solved by mixed-integer programming. A real-world example is presented for the same. The minimum number of capacitors that could achieve the target impedance over the desired frequency range are found along with their optimal locations. In order to solve an industrial problem, the s-parameters data of power plane geometry and capacitors are used for the accurate analysis including bulk capacitors and VRM. © 2014 IEEE.