We have engineered nano-sized constructs from erythrocytes doped with the FDA-approved near infrared (NIR) chromophore, indocyanine green (ICG). Herein, we present results that demonstrate membrane cholesterol enrichment is associated with reduced uptake of these nanoparticles by macrophages in vitro, and greater accumulation of the nanoparticles in intraperitoneal implants in immunodeficient mice. These preliminary findings suggest that cholesterol-enrichment of erythrocyte-derived optical nanoparticles can provide a potential capability for enhanced NIR imaging of tumors. © 2021 SPIE. All rights reserved.

Raviraj Vankayala

Department of Bioscience & Bioengineering

IIT Jodhpur

C.-H. Lee

J.C. Tang

J.T. Mac

T. Hanley

B. Anvari

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Flexibility in curriculum, in all its academic programs, encompassing elements of teaching, research, creativity, innovation and entrepreneurship is the most unique feature of IIT Jodhpur. The Department of Science and Technology (DST), under the National Mission on Cyber Physical Systems, has identified IIT Jodhpur as a Technology &amp; Innovation Hub in the area of Augmented Reality and Virtual Reality. The institute has also been nominated as the coordinator for the Jodhpur City and Knowledge Cluster by the Office of Principal Scientific Adviser, Government of India.

The sprawling 852-acre IIT Jodhpur campus is a majestic tribute to the deep-rooted diverse cultural heritage of the region. The campus is an architectural masterpiece, which is slated to become an international exemplar of sustainability with net-zero energy, and advanced water and waste management strategies.&rdquo;

Cholesterol-enriched erythrocyte-derived optical nanoparticles for NIR fluorescence imaging of intraperitoneal ovarian tumors in mice

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Cholesterol-enriched erythrocyte-derived optical nanoparticles for nir fluorescence imaging of intraperitoneal ovarian tumors in mice

Journal	Data powered by SciSpaceProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Publisher	Data powered by SciSpaceSPIE
ISSN	16057422