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Chiral phosphoric acid catalyzed enantioselective addition of thiols to in situ generated ketimines: Synthesis of N,S-ketals
R.A. Unhale, N. Molleti, , S. Dhanasekaran, S. Bhandary, V.K. Singh
Published in Elsevier Ltd
Volume: 58
Issue: 2
Pages: 145 - 151
The chiral Brønsted acid catalyzed enantioselective 1,2-addition of thiols to in situ generated ketimines, derived from 3-hydroxyisoindolinones, has been studied. The protocol provides a variety of isoindolinone-derived N,S-ketals in up to 98% yield and up to 99% enantioselectivity. The products have been converted to a known non-nucleoside HIV-1 reverse transcriptase inhibitor and a 1,3-thiazine derivative. © 2016 Elsevier Ltd
About the journal
JournalData powered by TypesetTetrahedron Letters
PublisherData powered by TypesetElsevier Ltd