This chapter presents the seismic vulnerability of Kathmandu City (Nepal), based on Nepal 2015 earthquake, in terms of the ground response and liquefaction potential. The spatially well-distributed 10-boreholes and ground motions of Mw 7.8 Nepal 2015 earthquake recorded at five different stations were adopted for the analysis. The range of peak ground acceleration and peak spectral acceleration were in the order of 0.21g-0.42g and 0.74g-1.50g, respectively. Liquefaction potential of the sites were computed using both semi-empirical approach and liquefaction potential index (LPI). LPI shows that the 6 sites out of 10 sites are at high risk of liquefaction. Copyright © 2020, IGI Global. Copying or distributing in print or electronic forms without written permission of IGI Global is prohibited.