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Bio-hydrogel for prolonged controlled gastro-retentive drug dispenser
T. Bhakat, A. Roy, , N.N. Sharma, S.U. Belgamwar
Published in Institute of Electrical and Electronics Engineers Inc.
A carbohydrate based polyacrylamide (Paam) modified with guar gum (GG) bio-hydrogel was developed for triggered, controlled gastro-retentive drug dispenser (GRDD) application. Temperature was applied as external stimuli and acidic medium (pH4) was used to release the drug from gel network. The release phenomenon was observed until 60 hours to understand the suitability for prolonged gastro retentive drug dispensing vehicle. The cytotoxicity was assessed by XTT assay with MCF-7 cell line. © 2019 IEEE.