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Autophagy based cellular physiological strategies target oncogenic progression
Prashant Kumar, Yuvraj Jagtap Anandrao, Som Patwa Mohanlal, Sumit Kinger, Ankur Dubey Rakesh, Vijay Prajapati Kumar, Rohan Dhiman, Krishna Poluri Mohan,
Published in WILEY
Evidence accumulated from past findings indicates that defective proteostasis may contribute to risk factors for cancer generation. Irregular assembly of abnormal proteins catalyzes the disturbance of cellular proteostasis and induces the ability of abnormal cellular proliferation. The autophagy mechanism plays a key role in the regular clearance of abnormal/poor lipids, proteins, and various cellular organelles. The results of functional and effective autophagy deliver normal cellular homeostasis, which establishes supportive metabolism and avoids unexpected tumorigenesis events. Still, the precise molecular mechanism of autophagy in tumor suppression has not been clear. How autophagy triggers selective or nonselective bulk degradation to dissipate tumor promotion under stress conditions is not clear. Under proteotoxic insults to knockdown the drive of tumorigenesis, it is critical for us to figure out the detailed molecular functions of autophagy in human cancers. The current article summarizes autophagy-based theragnostic strategies targeting various phases of tumorigenesis and suggests the preventive roles of autophagy against tumor progression. A better understanding of various molecular partners of autophagic flux will improve and innovate therapeutic approaches based on autophagic-susceptible effects against cellular oncogenic transformation.
About the journal
JournalData powered by TypesetJOURNAL OF CELLULAR PHYSIOLOGY
PublisherData powered by TypesetWILEY
Open AccessNo