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An efficient and highly diastereoselective synthesis of carbocyclic spiropyrazolones via one-pot sequential dual organo-silver catalyzed Michael-hydroalkylation reactions
K. Shukla, S. Shah, , V.K. Singh
Published in Elsevier Ltd
Volume: 60
Issue: 1
Pages: 92 - 97
An economical approach for the diastereoselective synthesis of highly functionalized carbocyclic spiropyrazolone derivatives having one quaternary and two tertiary stereocenters along with one exocyclic double bond exploiting dual organo-silver sequential catalysis has been developed. The unified method to both cyclohexyl and cyclopentyl spirocompounds involves the reaction of γ- and β-nitroalkynes with alkylidene pyrazolones catalyzed by Hünig's base followed by carbophilic activation of the triple bond with a Ag(I) salt leading to cyclization via hydroalkylation. © 2018
About the journal
JournalData powered by TypesetTetrahedron Letters
PublisherData powered by TypesetElsevier Ltd