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A facile and highly diastereoselective synthesis of carbocyclic spiro-pyrazolones via DABCO catalyzed Michael-Michael domino reaction
, K. Shukla, P. Mahto, R.K. Jha, V.K. Singh
Published in Elsevier Ltd
Volume: 74
Issue: 38
Pages: 5270 - 5279
An efficient domino Michael-Michael reaction of ω- and δ-nitro α,β-unsaturated esters with alkylidenepyrazolones has been accomplished using DABCO as the organocatalyst under mild reaction conditions. Under the present organocatalytic method, a wide range of carbocyclic spiro-pyrazolones with three tertiary stereogenic centers and a quaternary stereocenter has been prepared in high yields and excellent diastereoselectivities. An ester and nitro groups present in the spiro-pyrazolones have been utilized for further structural transformations. © 2018
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JournalData powered by TypesetTetrahedron
PublisherData powered by TypesetElsevier Ltd